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  • Suzhou Nanomicro Technology Co., Ltd.

  •  [Jiangsu,China]
  • Business Type:Manufacturer
  • Main Mark: Americas , Asia , Europe , Worldwide , Africa , Caribbean , East Europe , Middle East , North Europe , Oceania , Other Markets , West Europe
  • Exporter:31% - 40%
  • Certs:ISO9001, MSDS
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Suzhou Nanomicro Technology Co., Ltd.

Short Lead Time for for Separation Of Natural Products Monodisperse Spherical Silica Gel UniSil 5-500 supply to Puerto Rico Manufacturer

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Short Lead Time for for Separation Of Natural Products Monodisperse Spherical Silica Gel UniSil 5-500 supply to Puerto Rico Manufacturer

 UniSil® is a series of monodisperse spherical porous silica gels used for chromatography, produced by Suzhou Nanomicrotech Co. Ltd. from its unique patented technology that is developed in-house. UniSil® series of products meets the requirements of high performance liquid chromatography (HPLC) analysis in the laboratory and preparative separations in industry scale. Nanomicrotech is proud to be the leader of monodisperse chromatography silica gel with capability to produce in commercial scale.  

Silica Gel for Chromatography

Figure 1. SEM micrographs of UniSil® monodisperse chromatography silica gel

Features and Benefits of UniSil®

Features

Benefits

  High uniformity of particle size and perfect spherical shape

   Easy column packing, low back pressure, high efficiency and resolution

  Optimal pore structure

   High loading capacity and high selectivity

  Unique surface bonding technology

   Good acid and alkaline resistance, broad application pH range

  High mechanical strength

   Robust column packing and repacking, long lifetime

  Large scale production

   Consistent product quality, short delivery circle

High uniformity of particle size and perfect spherical shape

UniSil® silica gel media are made to in precise particle sizes with exceedingly high uniformity and perfect spherical shape (Figures 2 and 3). When compared to other commercial chromatography silica gels ( with broader particle size distribution), UniSil® has great advantages of easy column packing, low back pressure, high column efficiency, good resolution, stable column bed and reduced frit plugging.

 Chromatography UniSil

Figure 2. Comparison of UniSil® and well-known international brand chromatography silica gel

Silica Gel  UniSil


Figure 3. Particle size distribution of UniSil® and well-known international brand chromatography silica gel

Chromatography separation and purification


Figure 4. Flow characteristics in chromatography media of different particle size distributions

Optimal pore structure

The pore structure of silica gel has a great influence on its mechanical strength, separation ability, and loading capacity. Nanomicrotech not only controls precisely the particle size and size distribution of the silica gel, but also optimizes pore structure forming, desired surface area and pore volume. As the result, UniSil® silica gel has high loading capacity, strong mechanical strength, and superior separation capability.

Unique surface bonding technology

The selectivity and lifetime of a silica gel are often determined by the bonding phase on its surface and end-capping. In addition to the world leading technology of making silica gel, Nanomicrotech has developed unique techniques of surface bonding and end-capping, which enable UniSil® to be used with a broad pH range of application, good separation selectivity, and peak symmetry. To meet customer needs, Nanomicrotech also provides a variety of polar and non-polar bonded phase silica gel(C18,C8,C4,Phenyl,NH2,CN,Diol).

Figure 5 showed the separation of various chemical substances by UniSil® 5-120 C18 reverse phase silica gel media, including pyridine (alkaline compound). The high column efficiency and sharp and symmetric peaks indicated the minimal residual silanol groups on the surface (due to good end-capping).

Monodisperse microspheres  

Figure 5. Chromatographic separation of various compounds by UniSil® 5-120 C18


Exceptional chemical stability and resistance against acid and base

Nanomicrotech`s unique bonding and end-capping techniques gave UniSil® exceptional resistance to acidic and alkaline environment.  Figure 6 showed a comparison of UniSil® 10-100 C8 with a leading commercial brand, in terms of column efficiency (after alternating elution of columns with acidic and alkaline solutions).  The results indicated that the column packed with UniSil® maintains the column efficiency much better than the other with commercial silica gels, suggesting a stronger resistance against acid and base.

HPLC analysis


Figure 6. Comparison of column efficiency, between UniSil® 10-100 C8(green)and leading commercial brand(red), after treatment with acid and base  


Large scale production capability and lot-to-lot consistency

State-of-the-art manufacturing facility at Nanomicrotech allows a large scale production of UniSil® to meet the demands of industrial separation. Good quality control system also assures the high quality and good lot-to-lot consistency (as shown in Figure 7).

HPLC packing materials


Figure 7. Lot-to-lot consistency of UniSil® silica gel


Applications

Nanomicrotech has an in-house application development group with vast experiences. This group provides customers with a lot of technical services, from process development to technical transfer for production (industrial scale). UniSil® silica gel media have been successfully applied to the isolation and purification, including plant extracts(huperzine A, ginkgolide, panax notoginseng saponins), antibiotics(vancomycin, daptomycin, caspofungin, tiacumicin, Pneumocandin B0, cyclosprin, erythromycin), polypeptides (tacrolimus, thymalfasin, bivalirudin)and others(cod liver oil, bortezomib, flurbiprofen axetil), etc.

List of Products

Nanomicrotech supplies spherical silica gel media in the size range of 1.7 to 50 μm, with different pore sizes, meeting the needs of high performance chromatographic (HPLC) analysis in the lab and also preparative separation in industrial scale.

Products

Particle Size

Pore Size

Base Material

Functional Groups

μm

Å

UniSil®

1.7,3,5,10,20,30

60,100,120,200,300,500

Silica

None,C18,C8,C4,NH2,Phenyl,CN,Diol

NMSil

40~75,75~180

100

Silica

None,C18,C8,C4,NH2,Phenyl,CN,Diol


We insist about the theory of growth of 'High excellent, Performance, Sincerity and Down-to-earth working approach' to offer you with great company of processing for Monodisperse Spherical Silica Gel UniSil 5-500. The product will supply to all over the world, such as: Sweden,Egypt,Antarctica. We are willing to cooperate with business friends from at home and abroad and create a great future together.

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