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  • Suzhou Nanomicro Technology Co., Ltd.

  •  [Jiangsu,China]
  • Business Type:Manufacturer
  • Main Mark: Americas , Asia , Europe , Worldwide , Africa , Caribbean , East Europe , Middle East , North Europe , Oceania , Other Markets , West Europe
  • Exporter:31% - 40%
  • Certs:ISO9001, MSDS
  • Description:Deionizers With Ion Exchange Resins,Water Softener Resin Beads,Ion Exchange Filter
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Suzhou Nanomicro Technology Co., Ltd.

Deionizers With Ion Exchange Resins,Water Softener Resin Beads,Ion Exchange Filter

Home > Products > Chromatography Media - Monodisperse > Ion Exchange Chromatography Media > Ion Exchange Chromatography Media UniGel 80CM

Ion Exchange Chromatography Media UniGel 80CM

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Basic Info

Model No.: UniGel 80CM

Functional Group: -CH2COO

Additional Info

Transportation: Ocean,Air

Product Description

UniGel ion exchange media are made of hydrophilic acrylic microspheres with special functionalization on the surface. They provide a loading capacity twice as high as traditional ion exchange media, while resistant to high ionic strength. UniGel series are uniform in particle size, with optimal hydrophilicity, good mechanical strength, and excellent chemical stability; these features make them particularly suitable for capture step (initial separation) in downstream processing.

Nanomicrotech offers UniGel,Uni,UniMSP, and Nano series of monodisperse Ion Exchange Chromatography Media using a unique de novo synthesis technology that is developed in-house. These ion exchange media meet the demands of downstream processing,from capture, intermediate purification, polishing and analysis. UniGel series possess a strong absorption capability toward biomolecules, evenunder considerably high ionic strength; therefore they are well-suited for thecapture and initial purification of proteins. Uni series feature outstanding resolution, high loading capacity, and lownon-specific adsorption, making them ideal for intermediate purification ofproteins. Nanoseries aresmaller in particle size, which is designed specifically for fine separation andanalysis of proteins. All these types of media (resins) have thecharacteristics of high rigidity, good chemical stability, high resolution, lowback pressure, and long lifetime, meeting the requirements of bio-analysis,separation, and manufacturing.

Uniseries ion exchange media are made from highlycross-linked acrylic microspheres with a hydrophilic coating; subsequently the desiredion exchange functional groups are later introduced onto the surface. Complete hydrophilic coating greatly reducesthe non-specific adsorption between the stationary phase and biomolecules, assuringa better yield. The unique coating and derivatization technology enables Uni seriesmedia to have a high dynamic loading capacity of proteins. Uni series media are ideal for efficient separation of biomolecules suchas proteins, Nucleic Acids, polypeptides etc.

UniMSP series are multi-modal ion exchange media, with thesame base resin and hydrophilic coating as Uni series. The co-existence of bonded ion exchange functional groups andsurface hydrophobic groups leads to a mixed interaction of both ion exchangeand hydrophilicity. In some cases of purification, UniMSP series couldshow improved selectivity and resolution, they could also tolerate sampleloading at high conductivity.

Features ofNano-Micro Tech Ion Exchange Media

HighUniformity of Particle Size

Nanomicrotech manufactures ion exchange media of highly uniformparticle sizes (Fig. 1), with precise pore structures. The product line includes UniGel, Uni , and Uni MSP series mediabased on polyacrylic matrix, and Nano series of media based on poly(styrene-co-divinylbenzene, PS/DVB). All ion exchangemedia from Nanomicrotech come with distinct advantages of lot-to-lotreproducibility, easy column packing, etc.

Deionizers With Ion Exchange Resins

Figure 1.SEM micrographs of IEX mediafrom Nanomicro Tech (left) and an international market leader (right)

OutstandingMechanical Strength

Nanomicrotech IEX media are made from highly cross-linked polyacrylicor poly(styrene-co-divinylbenzene, PS/DVB). They have a remarkable advantage ofoutstanding mechanical strength, when compared with those ion exchange resinsbased on dextran or agarose. Nanomicrotech IEX media have shown little changein bed volume (Fig. 2), with increasing flow rate or pressure. This featuregreatly improves efficiency of downstream processing, and it also addresses theneed for a linear scale-up from the lab to manufacturing.

Water Softener Resin Beads

Figure 2. Comparisonof a polyacrylic IEX media from Nanomicrotech and an agarose IEX media from a commercialsupplier (pressure vs. flow ratecurve)

Good Chemical Stability

NanomicrotechIEX media are made from highly cross-linked polyacrylic orpoly(styrene-co-divinylbenzene). They maintaina good stability over a wide range of pH, which gives customer more rooms ofoperation (parameters/conditions) to achieve process development andoptimization.

Ion Exchange Filter

Figure3. Alkaline resistance test of UniÒ series of ion exchangemedia

High Resolution

Nanomicrotech IEX media have shown higherresolution and better recovery than a competitor`s IEX media in the separationof biomolecules, such as proteins, nucleic acids, polypeptides, andpolysaccharides (Fig. 4 & 5).

Ion Exchange Water

Figure 4. UniÒCM-50XS vs. a competitor`s IEX medium inseparation of proteins

Ion Exchange Resin Mechanism

Figure5. NanoSP-10L in Separation Of Proteins

High Loading Capacity

With uniformparticle sizes, optimized pore structure, and unique surface coating/derivatization,Nanomicrotech IEX media have higher loading capacity than internationalcompetitor`s IEX media (Fig. 6).

Resin Ion Exchange

Figure 6. Comparison of dynamic loadingcapacity of Lysozyme, UniGel-80DEAE vs. an international competitor`s IEX medium

Dowex Ion Exchange Resin

Figure 7. Dynamic loading capacity of UniGel-80DEAE underdifferent linear flow rates

Listof Products

Series

Products

Particle Size

Pore Size

Functional Groups

Features

Applications

μm

Å

UniGelÒ

UniGel®-30/80CM/

SP/DEAE/Q

30,80

XS:300

S:500

L:1000

CM: -CH2COO-

SP: -(CH2)3SO3-

DEAE:

-(CH2)2N(C2H5)2

Q: -CH2N+(CH3)3

High loading capacity/salt resistance

Capture/intermediate purification

UniÒ

UniÒCM/SP/

DEAE/Q-30S/

50XS

30,55

Low non-specific adsorption

Intermediate purification/polishing

UniÒMSP

UniÒMSP -30/50XS

30,55

Mixed mode/good selectivity/salt resistance

Intermediate purification/polishing

Nano

NanoSP/Q-5/

10/15/30L

5,10,15,30

High resolution/

mechanical strength

Polishing/analytical detection

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Product Categories : Chromatography Media - Monodisperse > Ion Exchange Chromatography Media

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