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  • Suzhou Nanomicro Technology Co., Ltd.

  •  [Jiangsu,China]
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  • Description:What Is Chromatography In Chemistry,Counter Current Chromatography,Affinity Column Chromatography
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Suzhou Nanomicro Technology Co., Ltd.

What Is Chromatography In Chemistry,Counter Current Chromatography,Affinity Column Chromatography

Home > Products > Chromatography Media - Monodisperse > Polymeric Chromatography Media > Polymeric Chromatography Media UniPS 15-300

Polymeric Chromatography Media UniPS 15-300

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Basic Info

Model No.: UniPS 15-300

Pore Size: 300 Å

Additional Info

Transportation: Ocean,Air

Product Description

These Chromatography Media are made from polystyrene (UniPS®), polymethyl methacrylate (UniPMM), copolymers of polystyrene and polymethyl methacrylate (UniPSN).Nanomicrotech`s monodisperse Polymeric Chromatography Media have been successfullyapplied to the isolation and Purification Of Plant Extracts (taxol, docetaxel, huperzine, ascutellarin, stevioside, neomangiferin, myricetin, diosgenin, vinorelbine, ecdyson arbutin), antibiotics(vancomycin, derivatives of vancomycin, daptomycin, telavancin, caspofungin, Pneumocandin B0, teicoplanin, dalbavancin), polypeptides(thymalfasin, octreotide, oxytocin)and others(iohexol , iopamidol , acarbose).

The polymeric matrix, monodispersion and optimal porosity give rise to beneficial features of high resolution and loading capacity, strong rigidity, resistance against acid and base, low back pressure, long lifetime and low non-specific adsorption.Suzhou Nano-Micro Technology Company, Ltd. (Nanomicrotech) offers a new generation of monodisperse spherical polymeric chromatography media, produced using a patented technology that is developed in-house.


Features

Benefits

High uniformity of particle size and perfect spherical shape

Easy column packing, low back pressure, high efficiency and resolution

Optimal pore structure

High loading capacity and selectivity

Superior chemical and pH stability

Wider choice and cheaper CIP procedures , broad application pH range and long lifetime

High mechanical strength

Low back pressure and stable column bed

Large-scale manufacturing capability

Consistent product quality and supply

Full line of products

Wide options satisfying different needs

High uniformity of particle size

Our monodisperse polymeric media have perfect spherical shape, highly uniform particle size distribution, and precise particle size (Figures 1 and 2). Compared to other commercial chromatography media (with a broad particle size distribution in Figure 2), our media have demonstrated great advantages of strong rigidity, easy column packing, low back pressure, high column efficiency, good resolution, stable column bed and lower risk of frit-plugging.

Monodisperse Spherical Chromatography Media

Figure 1. SEM micrographs of UniPS® monodisperse spherical chromatography media

Well-known International Brands(green)

Figure 2. Particle size distribution of UniPS®(red)compared with well-known international brands(green)

Optimized pore structure

Pore size and specific surface area have a strong influence on the separation performance of chromatography media. The choice of a chromatography media with correct pore structure would improve the loading capacity, the column efficiency and the final purity of target molecule. We offer media with pore sizes typically from 50 Å up to 1000 Å.

SEM micrographs of UniPS

Figure 3. SEM micrographs of UniPS® with different pore sizes

Superior chemical and pH stability

UniPS® chromatography media, made from highly cross-linked polymers of styrene and divinylbenzen, have excellent pH stability over a wide range of pH 1-14. These chromatography media maintain their outstanding physical and chemical stability even in extremely acidic or alkaline solutions (for e.g. 1 M NaOH/HCL) and organic solvents (such as methanol, ethanol, acetone, n-propanol, isopropanol, DMSO, THF, acetonitrile, 6 M guanidine hydrochloride, etc.). UniPS® provides the customers a wider choice of conditions for process development and optimization. The outstanding chemical stability, have been proven to meet the requirements of Cleaning-in-Place (CIP) in cGMP operations. For example, the loading capacity and separation efficiency remain unchanged, after a UniPS® 10-300 column was soaked in 1 M NaOH at 60°C for 40 days (Figure 4, used for Insulin purification).

Insulin Loading Capacity

Figure 4. Insulin loading capacity (breakthrough curve), when a UniPS® 10-300 column was soaked in 1 M NaOH (at 60°C) for up to 40 days

Large-scale Manufacturing Capability and Product Performance Consistency

Our state-of-the-art manufacturing facilities enable the bulk production of media, and a good quality control system assures the highest quality and batch-to-batch reproducibility. Figures 6, 7 and 8 showed the results of the performance test of more than twenty different lots of the chromatography media, indicating the good batch-to-batch reproducibility in our production.

Nanomicrotech Polymeric Chromatography Media

Figure 5. Nanomicrotech polymeric chromatography media in bulk packings

Consistent Particle Size

Figure 6. Consistent particle size and distribution in different lots of UniPS®

Stable Pore Volume

Figure 7. Stable pore volume and specific surface area in different lots of UniPS®

Reproducible Isolation Of Four Proteins

Figure 8. Reproducible isolation of four proteins by different lots of UniPS®

Different Polarity in Monodisperse Polymeric Chromatography Media

Nanomicrotech provides customers more choices of different materials and surface polarity, for process optimization, for example UniPS®, UniPSN and UniPMM, with increasing surface polarity in that order.

Applications

Nanomicrotech has an in-house application development group with vast experiences. This group support customers with a lot of technical services, from process development to technical transfer for production at industrial scale.

List of Products

List of typical particle and pore sizes of Nano-Micro Tech monodisperse spherical polymeric chromatography media*:

Products

Particle Size

Pore Size

Base Material

μm

Å

UniPS®

300

5,10,15,30,40

100,300,500,1000

PS/DVB

UniPS® RPC-NP

1.7,3,5,10

NP(non-porous)

PS/DVB

UniPSN

30,40,60

300

Poly DVB/acrylic

UniPMM

40

500

Poly acrylic

NM

50~150,150~300

300

PS/DVB

* Custom-made particle and pore sizes are available upon request.

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Product Categories : Chromatography Media - Monodisperse > Polymeric Chromatography Media

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